Cellular response to sterol depletion

Across TCGA patient cohorts, RNA activity of the Cellular response to sterol depletion pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOLC1_S538, RPL21, and RRS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to sterol depletion activity versus NOLC1_S538 in OV (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NOLC1_S538 →	-0.745	-0.043	.003	<.001	3	6
CCRCC	RPL21 →	-0.253	-0.053	.002	.002	3	5
GBM	RRS1 →	-0.595	-0.066	<.001	.002	3	5
LUAD	BCCIP →	-0.513	-0.053	<.001	<.001	3	5
LSCC	DDX21 →	-0.514	-0.059	<.001	<.001	3	5
LUAD	DDX21_S121 →	-0.737	-0.051	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071501 vs NOLC1_S538 — OV

Explore this scatter interactively →