Cellular response to sterol depletion

Across TCGA patient cohorts, RNA activity of the Cellular response to sterol depletion pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HHLA3-AS1, RAB5C, and GZF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to sterol depletion activity versus HHLA3-AS1 in UCEC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HHLA3-AS1 →	+0.759	+0.813	.003	.008	3	3
BRCA	RAB5C →	-0.339	-0.706	.006	.002	2	4
BRCA	GZF1 →	-0.266	-0.625	.007	.004	3	3
BRCA	ATP6V1FNB →	-0.166	-0.496	.002	.007	3	3
OV	TSEN2P1 →	-0.127	-0.129	<.001	<.001	3	3
COAD	PNLIP →	-0.021	-0.540	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071501 vs HHLA3-AS1 — UCEC

Explore this scatter interactively →