Cellular response to sterol depletion

Across TCGA cell cohorts, RNA activity of the Cellular response to sterol depletion pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNE4, ARHGAP29, and RIMKLA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SYNE4 grouped by Cellular response to sterol depletion-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SYNE4 →	+1.671	+1.347	.001	.001	3	3
BLOOD_Myeloma	ARHGAP29 →	+0.080	+1.461	.007	.001	3	3
LUNG_NSCLC_LUAD	RIMKLA →	+0.571	+0.740	.001	.001	3	3
URINARY_TRACT	TSHZ1 →	-0.930	-1.936	.002	<.001	3	3
URINARY_TRACT	MYO6 →	+2.525	+2.225	.007	<.001	2	4
LUNG_SCLC	TMEM179B →	+0.717	+0.745	.001	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SYNE4 by Cellular response to sterol depletion activity — OESOPHAGUS

Explore this box plot interactively →