Cellular response to sterol depletion

Across TCGA cell cohorts, RNA activity of the Cellular response to sterol depletion pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERLIN2, HOXA3, and CDX2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to sterol depletion activity versus ERLIN2 in LARGE_INTESTINE (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ERLIN2 →	+1.380	+1.933	<.001	<.001	3	3
OESOPHAGUS	HOXA3 →	-1.726	-1.807	.002	<.001	3	2
LARGE_INTESTINE	CDX2 →	+2.555	+1.619	.005	.001	3	2
LUNG_SCLC	PHYHD1 →	+4.573	+1.869	.006	.001	3	2
LUNG_SCLC	ATP8B1 →	+2.160	+1.470	.009	.005	3	2
LARGE_INTESTINE	UQCRC1 →	+1.029	+1.630	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071501 vs ERLIN2 — LARGE_INTESTINE

Explore this scatter interactively →