Cellular response to nitrosative stress

Across TCGA patient cohorts, RNA activity of the Cellular response to nitrosative stress pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG5, STOX1, and DDIT3, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to nitrosative stress activity versus ATG5 in UCS (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	ATG5 →	+0.734	+0.070	<.001	<.001	2	26
CHOL	STOX1 →	-1.391	-0.084	<.001	<.001	3	21
UVM	DDIT3 →	+0.957	+0.053	<.001	<.001	3	20
TGCT	RAI1 →	-1.427	-0.062	<.001	<.001	3	19
CHOL	RWDD1 →	+0.511	+0.056	<.001	<.001	3	18
TGCT	SCAP →	-0.534	-0.049	.001	<.001	2	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071500 vs ATG5 — UCS

Explore this scatter interactively →