Cellular response to nitrosative stress

Across TCGA patient cohorts, RNA activity of the Cellular response to nitrosative stress pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R14C, NUP210, and PLCL2_S123, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to nitrosative stress activity versus PPP1R14C in PDAC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PPP1R14C →	+0.905	+0.053	<.001	<.001	3	4
UCEC	NUP210 →	-0.341	-0.070	.003	<.001	3	4
HNSC	PLCL2_S123 →	+0.681	+0.102	.003	.004	3	4
LUAD	WDR44 →	+0.140	+0.033	<.001	.004	3	4
LUAD	MITF →	+0.257	+0.047	<.001	<.001	3	4
GBM	SNX6 →	+0.213	+0.058	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071500 vs PPP1R14C — PDAC

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