Cellular response to laminar fluid shear stress

Across TCGA cell cohorts, RNA activity of the Cellular response to laminar fluid shear stress pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBE1, RPS25, and EHD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to laminar fluid shear stress activity versus GBE1 in BREAST (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GBE1 →	+1.162	+0.346	<.001	<.001	3	4
BLOOD_Myeloma	RPS25 →	+1.373	+0.339	.001	.004	3	3
BONE	EHD1 →	+1.246	+0.245	.005	.005	3	3
BONE	ATP5MF →	-1.224	-0.297	.001	.002	3	3
BONE	MRPS6 →	+1.202	+0.295	<.001	.006	3	3
OVARY	CCN1 →	+2.588	+0.407	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071499 vs GBE1 — BREAST

Explore this scatter interactively →