Cellular response to fluid shear stress

Across TCGA patient cohorts, RNA activity of the Cellular response to fluid shear stress pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFXN3, TMEM97, and RRAS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to fluid shear stress activity versus SFXN3 in LSCC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SFXN3 →	+0.418	+0.670	.001	.003	3	5
PDAC	TMEM97 →	-0.980	-0.425	<.001	<.001	3	5
LSCC	RRAS →	+0.426	+0.633	<.001	.002	3	5
LSCC	EDNRA →	+0.613	+0.534	<.001	.009	3	5
LSCC	HTRA1 →	+0.903	+0.814	<.001	.001	3	5
LSCC	LIPT2 →	-0.679	-0.838	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071498 vs SFXN3 — LSCC

Explore this scatter interactively →