Cellular response to UV-C

pathway activity — cross-omics
GO:0071494Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cellular response to UV-C pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPA4, ENO1, and LIG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCACPA4 →+0.974+0.799.009<.00134
BRCAENO1 →+0.426+0.545.006.00234
HNSCLIG1 →+0.553+0.683.005.00633
BRCAGARS1 →+0.389+0.835.006<.00133
BRCAPHF19 →+0.415+0.500.002.00533
BRCAIL2RA →+0.764+0.977.002<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration