Cellular response to UV-B

Across TCGA patient cohorts, RNA activity of the Cellular response to UV-B pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAVIN3, CAVIN3_S62, and CNN2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to UV-B activity versus CAVIN3 in UCEC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CAVIN3 →	+0.621	+0.056	.004	.001	3	8
LSCC	CAVIN3_S62 →	+0.781	+0.093	<.001	<.001	3	8
BRCA	CNN2 →	+0.619	+0.060	<.001	<.001	3	8
BRCA	COPZ2 →	+0.718	+0.057	<.001	<.001	3	8
CCRCC	PDLIM5 →	+0.761	+0.064	<.001	<.001	3	8
BRCA	TIMP2 →	+0.839	+0.063	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071493 vs CAVIN3 — UCEC

Explore this scatter interactively →