Cellular response to UV-B

Across TCGA patient cohorts, RNA activity of the Cellular response to UV-B pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM272, EZH1, and FAM153B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to UV-B activity versus TMEM272 in GBM (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TMEM272 →	-0.466	-0.398	.004	.006	3	4
HNSC	EZH1 →	-0.314	-0.310	.004	.001	3	4
GBM	FAM153B →	-0.313	-0.323	.002	.008	3	3
GBM	PTGDR2 →	-0.446	-0.402	.004	.005	3	3
LUAD	MYL6P4 →	-0.375	-0.187	.001	.003	3	3
HNSC	PLCB4 →	-1.655	-0.489	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071493 vs TMEM272 — GBM

Explore this scatter interactively →