Cellular response to UV-B

Across TCGA cell cohorts, RNA activity of the Cellular response to UV-B pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTCHD4, CDKN1A, and RRM2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTCHD4 grouped by Cellular response to UV-B-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PTCHD4 →	-1.728	-1.454	<.001	<.001	3	5
SKIN	CDKN1A →	-2.561	-1.107	<.001	<.001	3	4
SKIN	RRM2B →	-0.852	-1.145	.003	.002	3	4
SOFT_TISSUE	SESN1 →	-1.516	-1.547	.003	.004	3	4
CNS	KCNJ16 →	-0.088	-1.067	.007	<.001	3	4
SOFT_TISSUE	EPHX2 →	-2.215	-1.538	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTCHD4 by Cellular response to UV-B activity — SKIN

Explore this box plot interactively →