Cellular response to UV-B

Across TCGA cell cohorts, RNA activity of the Cellular response to UV-B pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRIP1, GALNT18, and STRN4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to UV-B activity versus CRIP1 in BLOOD_Leukemia (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CRIP1 →	+2.371	+0.620	<.001	<.001	3	5
PANCREAS	GALNT18 →	-2.196	-0.331	.001	.001	3	4
SKIN	STRN4 →	-0.386	-1.100	.009	.002	3	4
STOMACH	PRSS53 →	-0.875	-0.319	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ERMAP →	-0.883	-1.614	<.001	<.001	3	3
BLOOD_Leukemia	TFPI →	-1.958	-0.437	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071493 vs CRIP1 — BLOOD_Leukemia

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