Cellular response to light stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to light stimulus pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM50B, HLA-DRA, and TMEM53, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM50B grouped by Cellular response to light stimulus-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TMEM50B →	+0.713	+0.169	.007	.005	3	4
LUNG_NSCLC_LUAD	HLA-DRA →	-2.643	-0.180	.006	<.001	3	4
STOMACH	TMEM53 →	+0.739	+0.099	.005	.008	3	4
LUNG_SCLC	SLC29A1 →	+0.957	+0.148	.001	.005	3	4
LIVER	TBC1D30 →	+2.224	+0.126	<.001	.008	3	4
CNS	SPACA9 →	-0.660	-0.148	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM50B by Cellular response to light stimulus activity — KIDNEY

Explore this box plot interactively →