Cellular response to light stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to light stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC50, ZCCHC24, and PPA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to light stimulus activity versus CCDC50 in BONE (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CCDC50 →	-1.607	-0.258	.006	.002	3	5
LIVER	ZCCHC24 →	-1.557	-0.250	.009	.003	3	4
LIVER	PPA1 →	+0.901	+0.248	.006	.004	3	4
BREAST	SLC39A13 →	-0.692	-0.159	.009	.004	3	4
KIDNEY	RNF144B →	+1.756	+0.224	.005	.001	3	4
LUNG_NSCLC_LUAD	PPP1R3C →	-2.195	-0.227	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071482 vs CCDC50 — BONE

Explore this scatter interactively →