Cellular response to gamma radiation

Across TCGA patient cohorts, RNA activity of the Cellular response to gamma radiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DENND2D, SULF1, and C1S, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to gamma radiation activity versus DENND2D in LSCC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DENND2D →	-0.269	-0.060	<.001	<.001	3	7
OV	SULF1 →	+0.822	+0.041	.001	.003	3	6
OV	C1S →	+0.608	+0.061	<.001	<.001	3	6
OV	CCDC80 →	+0.599	+0.036	.001	.002	3	6
BRCA	CACNA2D1 →	+0.511	+0.032	<.001	.001	3	6
BRCA	FSTL1 →	+0.414	+0.028	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071480 vs DENND2D — LSCC

Explore this scatter interactively →