Cellular response to gamma radiation

Across TCGA patient cohorts, RNA activity of the Cellular response to gamma radiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NR3C2, CYP4V2, and ROBO2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to gamma radiation activity versus NR3C2 in LUAD (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NR3C2 →	-0.930	-0.245	<.001	<.001	3	6
OV	CYP4V2 →	-0.472	-0.094	.008	.008	3	5
OV	ROBO2 →	-0.494	-0.100	<.001	.005	3	5
GBM	RFWD3 →	+0.287	+0.180	.005	.008	3	4
HNSC	PTGER2 →	-0.624	-0.155	.004	.001	3	4
LUAD	CHEK1 →	+0.860	+0.230	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071480 vs NR3C2 — LUAD

Explore this scatter interactively →