Cellular response to gamma radiation

Across TCGA cell cohorts, RNA activity of the Cellular response to gamma radiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PANK1, CXCL8, and BTBD19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PANK1 grouped by Cellular response to gamma radiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PANK1 →	+0.227	+0.198	<.001	.002	3	4
SKIN	CXCL8 →	-0.159	-0.147	.001	.001	3	4
OVARY	BTBD19 →	-0.193	-0.233	.001	.002	3	4
BLOOD_Leukemia	RBCK1 →	+0.229	+0.225	<.001	.001	3	3
BLOOD_Leukemia	ZNF217 →	+0.187	+0.162	.006	<.001	3	3
BLOOD_Leukemia	PPP1R3B →	+0.275	+0.156	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PANK1 by Cellular response to gamma radiation activity — BLOOD_Leukemia

Explore this box plot interactively →