Cellular response to ionizing radiation

Across TCGA patient cohorts, RNA activity of the Cellular response to ionizing radiation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPD2, CUEDC2, and TIMELESS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to ionizing radiation activity versus NCAPD2 in PDAC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NCAPD2 →	+0.564	+0.155	.001	.002	3	4
CCRCC	CUEDC2 →	+0.293	+0.214	<.001	.002	3	4
PDAC	TIMELESS →	+0.427	+0.130	<.001	.006	3	4
PDAC	CHTF18 →	+0.287	+0.112	<.001	.002	3	4
CCRCC	SSRP1 →	+0.280	+0.203	<.001	.008	3	4
PDAC	RRM1 →	+0.397	+0.171	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071479 vs NCAPD2 — PDAC

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