Cellular response to ionizing radiation

Across TCGA cell cohorts, RNA activity of the Cellular response to ionizing radiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUPR1, COL5A2, and POLR2I, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUPR1 grouped by Cellular response to ionizing radiation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NUPR1 →	-1.801	-0.287	.007	.002	3	6
UPPER_AERODIGESTIVE_TRACT	COL5A2 →	-2.744	-0.199	.005	<.001	3	4
SOFT_TISSUE	POLR2I →	+0.956	+0.277	<.001	.004	3	4
LUNG_NSCLC_LUSC	CYP2J2 →	+1.108	+0.347	.002	.008	3	4
PANCREAS	ARSA →	-0.867	-0.226	.007	.002	3	4
SKIN	IKZF4 →	+0.445	+0.210	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUPR1 by Cellular response to ionizing radiation activity — PANCREAS

Explore this box plot interactively →