Cellular response to ionizing radiation

Across TCGA cell cohorts, RNA activity of the Cellular response to ionizing radiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHMP6, OSGIN1, and NEXN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to ionizing radiation activity versus CHMP6 in LUNG_NSCLC_LUAD (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CHMP6 →	+0.504	+0.146	.001	<.001	3	5
BONE	OSGIN1 →	+1.670	+0.236	.002	.001	3	4
BONE	NEXN →	+4.223	+0.335	.001	.001	3	4
BONE	SUPT4H1 →	+0.618	+0.304	.006	.005	3	4
PANCREAS	CCDC88B →	+0.902	+0.137	.005	.008	3	4
BREAST	ANKS1B →	+1.003	+0.214	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071479 vs CHMP6 — LUNG_NSCLC_LUAD

Explore this scatter interactively →