Cellular response to radiation

Across TCGA cell cohorts, RNA activity of the Cellular response to radiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GJD3, EIF1B, and ZNF3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GJD3 grouped by Cellular response to radiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GJD3 →	+0.805	+0.128	.004	.003	3	5
BLOOD_Leukemia	EIF1B →	+0.562	+0.129	.005	.001	3	4
BLOOD_Leukemia	ZNF3 →	-0.500	-0.110	.006	.008	3	4
BLOOD_Leukemia	H1-2 →	+1.580	+0.139	.006	<.001	3	4
CNS	EVA1C →	-1.654	-0.179	<.001	.001	3	4
BREAST	TNFAIP8L2 →	+0.162	+0.132	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GJD3 by Cellular response to radiation activity — LARGE_INTESTINE

Explore this box plot interactively →