Cellular hypotonic response

Across TCGA patient cohorts, RNA activity of the Cellular hypotonic response pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GEMIN5, IMP4, and RBM25, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular hypotonic response activity versus GEMIN5 in GBM (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GEMIN5 →	-0.231	-0.092	<.001	<.001	3	8
PDAC	IMP4 →	-0.365	-0.060	.001	.004	3	8
LSCC	RBM25 →	-0.232	-0.088	<.001	<.001	3	8
OV	UTP14A →	-0.312	-0.051	.005	.004	3	7
PDAC	UTP15 →	-0.150	-0.041	.001	.003	3	7
OV	WDR36 →	-0.265	-0.069	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071476 vs GEMIN5 — GBM

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