Cellular hypotonic response

Across TCGA cell cohorts, RNA activity of the Cellular hypotonic response pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OVGP1, PKIB, and PANX1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OVGP1 grouped by Cellular hypotonic response-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OVGP1 →	+0.932	+0.829	<.001	<.001	3	5
KIDNEY	PKIB →	+1.928	+0.944	.008	.006	3	5
URINARY_TRACT	PANX1 →	-0.972	-1.768	.005	<.001	3	4
URINARY_TRACT	SNX4 →	+0.688	+1.404	<.001	<.001	3	4
URINARY_TRACT	CEACAM6 →	+3.633	+1.715	.008	<.001	3	4
BLOOD_Lymphoma	RIT1 →	-0.925	-1.286	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OVGP1 by Cellular hypotonic response activity — BREAST

Explore this box plot interactively →