Cellular hypotonic response

Across TCGA cell cohorts, RNA activity of the Cellular hypotonic response pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NR5A2, PPP1R12A, and KCNMB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NR5A2 grouped by Cellular hypotonic response-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NR5A2 →	-0.157	-0.082	.007	.001	2	6
SKIN	PPP1R12A →	+0.304	+0.096	<.001	<.001	3	4
LUNG_NSCLC_LUSC	KCNMB2 →	-0.339	-0.144	<.001	.006	3	4
BLOOD_Leukemia	TLR5 →	+0.222	+0.106	.001	<.001	3	4
LARGE_INTESTINE	UTP15 →	-0.241	-0.083	.006	.007	3	4
BLOOD_Myeloma	TRIM7 →	+0.408	+0.122	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NR5A2 by Cellular hypotonic response activity — CNS

Explore this box plot interactively →