Cellular hypotonic response

Across TCGA cell cohorts, RNA activity of the Cellular hypotonic response pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF1B, DHRS4, and LAMC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular hypotonic response activity versus EIF1B in URINARY_TRACT (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	EIF1B →	+0.657	+1.937	.002	<.001	2	5
URINARY_TRACT	DHRS4 →	+1.140	+1.769	.003	.004	3	4
URINARY_TRACT	LAMC2 →	-2.875	-2.062	<.001	<.001	2	5
SKIN	TTC34 →	+0.106	+0.846	.002	.002	3	4
URINARY_TRACT	ST13 →	+0.737	+1.677	.005	.003	3	3
URINARY_TRACT	AREG →	-2.930	-1.505	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071476 vs EIF1B — URINARY_TRACT

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