Cellular hyperosmotic response

Across TCGA patient cohorts, RNA activity of the Cellular hyperosmotic response pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3CG, IL10RA, and CSF2RB, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular hyperosmotic response activity versus PIK3CG in THYM (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	PIK3CG →	+1.277	+0.054	<.001	<.001	3	30
SCLC	IL10RA →	+1.329	+0.106	<.001	<.001	3	30
MESO	CSF2RB →	+1.289	+0.046	.001	.003	3	29
SCLC	ALOX5 →	+1.362	+0.117	<.001	<.001	3	29
SCLC	WDFY4 →	+0.948	+0.100	<.001	<.001	3	29
DLBC	PARP15 →	+1.739	+0.069	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071474 vs PIK3CG — THYM

Explore this scatter interactively →