Cellular hyperosmotic response

Across TCGA patient cohorts, RNA activity of the Cellular hyperosmotic response pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB1, ARHGAP9, and RAB42, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular hyperosmotic response activity versus LILRB1 in COAD (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LILRB1 →	+0.691	+0.166	.002	.005	3	5
COAD	ARHGAP9 →	+0.653	+0.203	<.001	<.001	3	5
PDAC	RAB42 →	+0.522	+0.154	.001	.004	3	5
CCRCC	ENTPD8 →	-0.686	-0.265	<.001	<.001	3	5
COAD	HCK →	+0.721	+0.212	.002	<.001	3	5
COAD	CD53 →	+0.674	+0.170	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071474 vs LILRB1 — COAD

Explore this scatter interactively →