Cellular response to salt stress

Across TCGA patient cohorts, RNA activity of the Cellular response to salt stress pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO9A, RCAN1, and ADGRF5-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to salt stress activity versus MYO9A in LUAD (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MYO9A →	+0.366	+0.121	.002	.009	3	5
LSCC	RCAN1 →	+0.547	+0.138	<.001	.005	3	4
LUAD	ADGRF5-AS1 →	+0.754	+0.127	.001	<.001	3	4
COAD	HECW2 →	+0.473	+0.114	<.001	.001	3	4
COAD	ANTXR1 →	+1.115	+0.137	<.001	<.001	3	4
COAD	PLPP4 →	+1.124	+0.185	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071472 vs MYO9A — LUAD

Explore this scatter interactively →