Cellular response to salt stress

Across TCGA cell cohorts, RNA activity of the Cellular response to salt stress pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANP32B, PPM1G, and KYNU, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANP32B grouped by Cellular response to salt stress-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ANP32B →	+0.318	+0.220	.001	.003	3	4
SKIN	PPM1G →	+0.623	+0.240	<.001	.002	3	4
SKIN	KYNU →	+2.664	+0.260	.001	.001	3	4
SKIN	PRPF4 →	+0.586	+0.206	<.001	<.001	3	4
SKIN	FN3K →	-1.562	-0.218	.001	.001	3	4
PANCREAS	PRR14L →	-0.831	-0.320	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANP32B by Cellular response to salt stress activity — BLOOD_Leukemia

Explore this box plot interactively →