Cellular response to salt stress

Across TCGA cell cohorts, RNA activity of the Cellular response to salt stress pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDNF, KRT17, and ZMIZ2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GDNF grouped by Cellular response to salt stress-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GDNF →	-0.338	-0.276	.002	.007	2	6
CNS	KRT17 →	-0.113	-0.179	<.001	.003	3	5
LUNG_NSCLC_LUSC	ZMIZ2 →	+0.316	+0.249	<.001	.006	3	4
LUNG_NSCLC_LUSC	RAG2 →	+0.207	+0.192	.001	<.001	3	4
URINARY_TRACT	ARHGAP26 →	-0.142	-0.192	.008	.002	3	4
KIDNEY	SAP30L →	+0.258	+0.206	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GDNF by Cellular response to salt stress activity — STOMACH

Explore this box plot interactively →