Cellular response to osmotic stress

Across TCGA patient cohorts, RNA activity of the Cellular response to osmotic stress pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK2, LCP1, and ARHGAP45, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to osmotic stress activity versus DOCK2 in GBM (Pearson r = 0.77).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DOCK2 →	+0.592	+0.091	<.001	<.001	3	8
BRCA	LCP1 →	+0.677	+0.045	<.001	<.001	3	8
GBM	ARHGAP45 →	+0.469	+0.069	<.001	<.001	3	8
GBM	FMNL1 →	+0.559	+0.094	<.001	<.001	3	8
OV	ANKRD44 →	+0.438	+0.040	.001	<.001	3	8
GBM	WAS →	+0.546	+0.086	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071470 vs DOCK2 — GBM

Explore this scatter interactively →