Cellular response to osmotic stress

Across TCGA cell cohorts, RNA activity of the Cellular response to osmotic stress pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTOR, DDX3X, and RPTOR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTOR grouped by Cellular response to osmotic stress-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MTOR →	-0.350	-0.323	<.001	.003	3	6
BONE	DDX3X →	-0.478	-0.350	.005	.007	2	7
SOFT_TISSUE	RPTOR →	-0.244	-0.206	.005	.006	2	6
CNS	GSTM2P1 →	-0.393	-0.331	.004	.004	3	5
BONE	CCL27 →	+0.337	+0.316	<.001	<.001	3	5
KIDNEY	ANGPTL5 →	-0.381	-0.283	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTOR by Cellular response to osmotic stress activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →