Cellular response to osmotic stress

Across TCGA cell cohorts, RNA activity of the Cellular response to osmotic stress pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC4A7, CBR3, and PCNP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to osmotic stress activity versus SLC4A7 in OVARY (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC4A7 →	+1.628	+0.315	<.001	.001	3	5
URINARY_TRACT	CBR3 →	+1.542	+0.393	.004	.009	3	4
OESOPHAGUS	PCNP →	+0.691	+0.298	.002	.004	3	4
LUNG_SCLC	PCMT1 →	+0.670	+0.277	.001	.001	3	4
BREAST	HSF2 →	+0.802	+0.389	<.001	<.001	3	4
LUNG_NSCLC_LUSC	B3GALT6 →	+1.162	+0.267	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071470 vs SLC4A7 — OVARY

Explore this scatter interactively →