Cellular response to xenobiotic stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to xenobiotic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTM5, NPR3, and GSTM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to xenobiotic stimulus activity versus GSTM5 in UCEC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSTM5 →	+0.678	+0.167	<.001	.002	3	6
LSCC	NPR3 →	+1.068	+0.141	.002	.005	3	5
LSCC	GSTM2 →	+0.829	+0.129	<.001	<.001	3	5
BRCA	COPZ2 →	+0.997	+0.145	<.001	.001	3	5
HNSC	MYH2 →	+2.594	+0.163	.003	<.001	3	5
UCEC	SVEP1 →	+0.607	+0.193	.006	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071466 vs GSTM5 — UCEC

Explore this scatter interactively →