Cellular response to xenobiotic stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to xenobiotic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C19orf71, KANSL1L, and CHRM4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C19orf71 grouped by Cellular response to xenobiotic stimulus-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C19orf71 →	-1.307	-0.845	.003	.008	3	4
KIDNEY	KANSL1L →	-1.231	-1.051	.003	.008	3	4
SOFT_TISSUE	CHRM4 →	-0.660	-0.868	.008	.004	3	3
LUNG_SCLC	ATAD2B →	-0.681	-1.157	.009	.003	3	3
KIDNEY	WDPCP →	-0.559	-0.745	.001	.003	3	3
LUNG_SCLC	POGLUT1 →	-1.000	-1.021	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C19orf71 by Cellular response to xenobiotic stimulus activity — SKIN

Explore this box plot interactively →