Cellular response to xenobiotic stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to xenobiotic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NQO1, DNAJC22, and GSR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to xenobiotic stimulus activity versus NQO1 in LUNG_SCLC (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NQO1 →	+2.285	+0.167	<.001	<.001	3	6
STOMACH	DNAJC22 →	+3.079	+0.392	.001	.001	3	5
LARGE_INTESTINE	GSR →	+1.002	+0.178	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	TM4SF19 →	-2.192	-0.312	.007	.005	2	6
BREAST	SELENBP1 →	+2.774	+0.199	.005	.004	3	5
BLOOD_Leukemia	INPPL1 →	+0.590	+0.175	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071466 vs NQO1 — LUNG_SCLC

Explore this scatter interactively →