Cellular response to water stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to water stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PIK3CA, FGB_T398, and QKI, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to water stimulus activity versus PIK3CA in GBM (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIK3CA →	+0.266	+0.074	<.001	<.001	3	6
LSCC	FGB_T398 →	-0.759	-0.065	.008	.007	3	5
UCEC	QKI →	+0.331	+0.091	<.001	<.001	3	5
UCEC	RSU1 →	+0.454	+0.079	<.001	<.001	3	5
BRCA	SPTLC2 →	-0.586	-0.046	<.001	.001	3	5
LUAD	WDR48_S335 →	+0.529	+0.066	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071462 vs PIK3CA — GBM

Explore this scatter interactively →