Cellular response to water stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to water stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAP1, LGALS1, and TIMP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to water stimulus activity versus CAP1 in LSCC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CAP1 →	+0.399	+1.034	<.001	<.001	3	5
LSCC	LGALS1 →	+0.864	+0.884	<.001	.002	3	4
PDAC	TIMP3 →	+0.982	+0.551	<.001	<.001	3	4
LUAD	RRAS →	+0.442	+0.265	<.001	.001	3	4
LSCC	HTRA1 →	+0.904	+0.809	<.001	.002	2	5
LSCC	CAVIN1 →	+0.785	+0.992	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071462 vs CAP1 — LSCC

Explore this scatter interactively →