Cellular response to water stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to water stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APBB1, ZNF296, and MRAS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APBB1 grouped by Cellular response to water stimulus-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	APBB1 →	-1.514	-1.024	.002	<.001	3	5
LUNG_NSCLC_LUSC	ZNF296 →	+1.297	+1.679	.002	<.001	3	5
URINARY_TRACT	MRAS →	-2.563	-1.677	.001	<.001	3	5
BREAST	RAB11FIP2 →	-0.641	-0.913	<.001	<.001	3	5
LARGE_INTESTINE	REEP2 →	-1.643	-1.401	<.001	<.001	3	4
OESOPHAGUS	TMCC2 →	-1.463	-1.145	.001	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APBB1 by Cellular response to water stimulus activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →