Cellular response to hyperoxia

Across TCGA patient cohorts, RNA activity of the Cellular response to hyperoxia pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PIP4K2A, VIM, and SMARCA4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to hyperoxia activity versus PIP4K2A in OV (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PIP4K2A →	+0.499	+0.057	<.001	.004	3	10
GBM	VIM →	+0.510	+0.168	<.001	<.001	3	9
LSCC	SMARCA4 →	-0.306	-0.097	<.001	<.001	3	8
LSCC	SNX2 →	+0.243	+0.120	<.001	<.001	3	8
GBM	WAS →	+0.493	+0.160	<.001	<.001	3	8
GBM	FOLR2 →	+0.935	+0.152	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071455 vs PIP4K2A — OV

Explore this scatter interactively →