Cellular response to hyperoxia

Across TCGA patient cohorts, RNA activity of the Cellular response to hyperoxia pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIMAP6, CCL21, and BIRC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to hyperoxia activity versus GIMAP6 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GIMAP6 →	+0.683	+0.473	<.001	<.001	3	4
BRCA	CCL21 →	+1.371	+0.388	.003	.001	3	4
CCRCC	BIRC3 →	+0.875	+0.480	.001	.001	3	4
BRCA	CPED1 →	+0.745	+0.321	<.001	.005	3	3
BRCA	GIMAP2 →	+0.742	+0.462	.002	<.001	3	3
OV	CXCL12 →	+1.003	+0.205	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071455 vs GIMAP6 — BRCA

Explore this scatter interactively →