Cellular response to hyperoxia

Across TCGA cell cohorts, RNA activity of the Cellular response to hyperoxia pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLCD1, SYT16, and JUP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLCD1 grouped by Cellular response to hyperoxia-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TLCD1 →	-0.647	-1.218	.008	<.001	3	5
URINARY_TRACT	SYT16 →	-2.550	-2.212	<.001	<.001	3	5
PANCREAS	JUP →	-2.352	-1.607	.009	<.001	3	5
PANCREAS	ANGEL2 →	+0.966	+1.589	<.001	<.001	3	5
LARGE_INTESTINE	TLCD2 →	-1.190	-1.033	<.001	.004	3	5
KIDNEY	RB1CC1 →	+0.673	+1.056	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLCD1 by Cellular response to hyperoxia activity — KIDNEY

Explore this box plot interactively →