Cellular response to hyperoxia

Across TCGA cell cohorts, RNA activity of the Cellular response to hyperoxia pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC20A1, SLIT2, and CCDC102B, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to hyperoxia activity versus SLC20A1 in PANCREAS (Pearson r = 0.99).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC20A1 →	+0.803	+2.394	.005	.003	2	2
PANCREAS	SLIT2 →	+1.423	+2.394	<.001	.003	2	2
PANCREAS	CCDC102B →	+0.566	+2.394	.008	.003	2	2
LUNG_NSCLC_LUAD	AMER1 →	+0.275	+0.298	.002	.007	2	2
PANCREAS	KLK5 →	+0.790	+2.606	.005	.001	2	2
PANCREAS	LGALS1 →	+1.589	+2.394	.004	.003	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071455 vs SLC20A1 — PANCREAS

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