Cellular response to oxygen radical

Across TCGA patient cohorts, RNA activity of the Cellular response to oxygen radical pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNXB, ADH1B, and PLAC9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to oxygen radical activity versus TNXB in CCRCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TNXB →	+0.949	+0.060	<.001	<.001	3	7
BRCA	ADH1B →	+1.185	+0.033	<.001	<.001	3	7
CCRCC	PLAC9 →	+0.829	+0.072	<.001	<.001	3	7
PDAC	ABCA8 →	+0.430	+0.039	<.001	.004	3	6
CCRCC	RPS2 →	-0.334	-0.068	<.001	<.001	3	6
CCRCC	SNTB2_S222 →	+0.706	+0.059	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071450 vs TNXB — CCRCC

Explore this scatter interactively →