Cellular response to oxygen radical

Across TCGA patient cohorts, RNA activity of the Cellular response to oxygen radical pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYVE1, ACKR1, and C7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to oxygen radical activity versus LYVE1 in LSCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LYVE1 →	+0.916	+0.152	<.001	.002	3	6
LSCC	ACKR1 →	+1.159	+0.140	<.001	<.001	3	6
LSCC	C7 →	+1.260	+0.120	.001	.008	3	5
CCRCC	CD36 →	+0.748	+0.117	.001	.009	3	5
BRCA	ADH1B →	+1.999	+0.199	<.001	<.001	3	5
BRCA	SEPTIN3 →	-1.392	-0.237	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071450 vs LYVE1 — LSCC

Explore this scatter interactively →