Cellular response to oxygen radical

Across TCGA cell cohorts, RNA activity of the Cellular response to oxygen radical pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COLGALT1, EXTL3, and SRGN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COLGALT1 grouped by Cellular response to oxygen radical-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	COLGALT1 →	-0.874	-1.451	.002	<.001	3	4
BREAST	EXTL3 →	-0.987	-1.080	.007	<.001	3	4
BREAST	SRGN →	-2.385	-0.989	.002	.002	3	4
STOMACH	ARHGEF25 →	-2.556	-0.929	<.001	.002	3	4
URINARY_TRACT	CHCHD4 →	-1.397	-0.515	.002	.004	3	3
LARGE_INTESTINE	SEC22C →	-0.719	-0.632	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COLGALT1 by Cellular response to oxygen radical activity — OVARY

Explore this box plot interactively →