Cellular response to oxygen radical

Across TCGA cell cohorts, RNA activity of the Cellular response to oxygen radical pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDX2, MYO5B, and SNAI1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to oxygen radical activity versus PRDX2 in CNS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRDX2 →	+2.193	+0.218	.004	.007	3	5
BONE	MYO5B →	-3.130	-0.285	.002	.008	3	4
BREAST	SNAI1 →	+0.800	+0.181	.006	<.001	3	4
BREAST	ZNF717 →	+1.060	+0.140	.001	.004	3	4
URINARY_TRACT	CRTC3 →	+0.746	+0.352	.001	.003	3	4
BLOOD_Leukemia	DNAH17 →	-0.494	-0.174	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071450 vs PRDX2 — CNS

Explore this scatter interactively →