Cellular response to hydroperoxide

Across TCGA patient cohorts, RNA activity of the Cellular response to hydroperoxide pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGDIB, DCN, and SERPINF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to hydroperoxide activity versus ARHGDIB in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARHGDIB →	+0.539	+0.596	<.001	<.001	3	5
LSCC	DCN →	+0.757	+0.462	<.001	<.001	3	5
BRCA	SERPINF1 →	+0.810	+0.413	.001	<.001	3	5
BRCA	PTH1R →	+0.584	+0.421	.004	.001	2	6
GBM	TNFAIP8L2 →	+0.791	+0.713	<.001	<.001	3	5
GBM	PLA2G15 →	+0.554	+0.647	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071447 vs ARHGDIB — LSCC

Explore this scatter interactively →