Cellular response to hydroperoxide

Across TCGA cell cohorts, RNA activity of the Cellular response to hydroperoxide pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D12, REXO2, and TNFRSF10D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to hydroperoxide activity versus TBC1D12 in LUNG_NSCLC_LUAD (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TBC1D12 →	-0.490	-0.740	.006	.009	3	4
LUNG_NSCLC_LUAD	REXO2 →	-0.853	-1.108	.003	<.001	3	4
BLOOD_Myeloma	TNFRSF10D →	-2.660	-0.404	<.001	.007	2	5
BLOOD_Lymphoma	MBTD1 →	+0.787	+1.038	.001	.008	3	4
CNS	CENPW →	-0.834	-1.323	<.001	<.001	3	4
OESOPHAGUS	KCNK7 →	+0.510	+1.120	.008	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071447 vs TBC1D12 — LUNG_NSCLC_LUAD

Explore this scatter interactively →